Daily MFG

 

 


Uro-Fit RESEARCH REFERENCE

Uro-Fit Kidney and Bladder Formula

Herbal Formula Combining Cranberry, Chanca Piedra, Dandelion Root and Uva Ursi

Daily "Uro-Fit" Kidney and Bladder Formula includes the best in nutritional ingredients known to traditional and modern health science for maintaining a healthy urinary tract. However, please do not simply take our word for that - study it for yourself. We have included a sampling of the research available. We have made a sincere effort to include a representative sampling of the available studies, including those showing both strong and weak results. Many more studies can be found by searching the National Library of Medicine at www.pubmed.gov.

It is important to realize that when searching the database at the National Library of Medicine you will find many studies supporting the use of Cranberry, Chanca Piedra, Dandelion Root, and Uva Ursi for conditions other than the urinary tract. This testifies to the fact that Uro-Fit would benefit anyone, even if they do not need urinary tract support. However, this combination has the strongest research backing for improving urinary health.

 

Cranberry Research

The cranberry powder used in Uro-Fit has been awarded an approved health claim for urinary health by the Korean Food and Drug Administration  (KFDA) and their review of the clinical data.

A list of research studies can also be found at: http://www.decasbotanical.com/documents/Studies%20Listed%2002%2024%2010.pdf

1. Vidlar A, Vostalova J, Ulrichova J, Student V, Stejskal D, Reichenbach R, Vrbkova J, Ruzicka F, and Simanek V. (2010) The effectiveness of dried cranberries (Vaccinium macrocarpon) in men with lower urinary tract symptoms. British Journal of Nutrition  104:1181-1189.

Link to full text:

http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=7912891&fulltextType=RA&fileId=S0007114510002059

 

2. Sengupta K, Alluri KV, Golaakoti T, Gottumukkala GV, Raavi L, Kotchrlakota L, Soigalan SC, Dey D, and Chatterjeee A. A randomized, double blind, controlled, dose-dependent clinical trial to evaluate the efficacy of a proanthocyanidin standarized whole cranberry (vaccinium macrocarpon) powder on infections of the urinary tract. (2011) Current Bioactive Compounds 7:39-46.

Link to full text:

http://www.decasbotanical.com/documents/UTICranberryFinal2010.pdf

Phytomedicine. 2012 Feb 3. [Epub ahead of print]

 

3. Wojnicz D, Sycz Z, Walkowski S, Gabrielska J, Aleksandra W, Alicja K, Anna SL, Hendrich AB. Study on the influence of cranberry extract Żuravit S·O·S(®) on the properties of uropathogenic Escherichia coli strains, their ability to form biofilm and its antioxidant properties. Phytomedicine. 2012 Feb 3. [Epub ahead of print].

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22306419

 

4. Stapleton AE, Dziura J, Hooton TM, Cox ME, Yarova-Yarovaya Y, Chen S, Gupta K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo Clin Proc. 2012 Feb;87(2):143-50.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22305026

 

5. Laplante KL, Sarkisian SA, Woodmansee S, Rowley DC, Seeram NP. Phytother Res. 2012 Effects of Cranberry Extracts on Growth and Biofilm Production of Escherichia coli and Staphylococcus species. Feb 1. doi: 10.1002/ptr.4592. [Epub ahead of print]

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22294419

 

6. Salo J, Uhari M, Helminen M, Korppi M, Nieminen T, Pokka T, Kontiokari T.Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trial. Clin Infect Dis. 2012 Feb 1;54(3):340-6. Epub 2011 Nov 18.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22100577

7. Suzanne E GeerlingsShould we prevent or even treat urinary tract infections with cranberries? Future MicrobiologyDecember 2011, Vol. 6, No. 12, Pages 1385-1386 .

Link to Full Text: http://www.futuremedicine.com/doi/pdf/10.2217/fmb.11.115

 

8. Shmuely H, Ofek I, Weiss EI, Rones Z, Houri-Haddad Y.Cranberry components for the therapy of infectious disease. Curr Opin Biotechnol. 2011 Nov 14. [Epub ahead of print]

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22088310

 

9. Ermel G, Georgeault S, Inisan C, Besnard M. Inhibition of adhesion of uropathogenic Escherichia coli bacteria to uroepithelial cells by extracts from cranberry. J Med Food. 2012 Feb;15(2):126-34. Epub 2011 Nov 14. Link to abstract: http://www.ncbi.nlm.nih.gov/pubmed/22082066

10. Iswaldi I, Gómez-Caravaca AM, Arráez-Román D, Uberos J, Lardón M, Segura-Carretero A, Fernández-Gutiérrez A. Characterization by high-performance liquid chromatography with diode-array detection coupled to time-of-flight mass spectrometry of the phenolic fraction in a cranberry syrup used to prevent urinary tract diseases, together with a study of its antibacterial activity. J Pharm Biomed Anal. 2012 Jan 25;58:34-41. Epub 2011 Oct 1.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22018892

 

11. Hidalgo G, Chan M, Tufenkji N.  Inhibition of Escherichia coli CFT073 fliC expression and motility by cranberry materials. Appl Environ Microbiol. 2011 Oct;77(19):6852-7. Epub 2011 Aug 5. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21821749

12. Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA, de Reijke TM, Prins JM, Koeijers J, Verbon A, Stobberingh E, Geerlings SE. Cranberries vs antibiotics to prevent urinary tract infections: a randomized double-blind noninferiority trial in premenopausal women. Arch Intern Med. 2011 Jul 25;171(14):1270-8.

13. Cowan CC, Hutchison C, Cole T, Barry SJ, Paul J, Reed NS, Russell JM. A randomised double-blind placebo-controlled trial to determine the effect of cranberry juice on decreasing the incidence of urinary symptoms and urinary tract infections in patients undergoing radiotherapy for cancer of the bladder or cervix. Clin Oncol (R Coll Radiol). 2012 Mar;24(2):e31-8. Epub 2011 Jun 23. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21703829

 

14. Tao Y, Pinzón-Arango PA, Howell AB, Camesano TA. Oral consumption of cranberry juice cocktail inhibits molecular-scale adhesion of clinical uropathogenic Escherichia coli. J Med Food. 2011 Jul-Aug;14(7-8):739-45. Epub 2011 Apr 11.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21480803

 

15. Huang Y, Nikolic D, Pendland S, Doyle BJ, Locklear TD, Mahady GB. Effects of cranberry extracts and ursolic acid derivatives on P-fimbriated Escherichia coli, COX-2 activity, pro-inflammatory cytokine release and the NF-kappabeta transcriptional response in vitro. Pharm Biol. 2009;47(1):18-25.    Link to Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849675/pdf/nihms-190676.pdf

16. Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study.   J Urol. 2008 Oct;180(4):1367-72. Epub 2008 Aug 15.  Link to Free Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631561/pdf/nihms70398.pdf

17. Barbosa-Cesnik C, Brown MB, Buxton M, Zhang L, DeBusscher J, Foxman B. Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomized placebo-controlled trial. Clin Infect Dis. 2011 Jan 1;52(1):23-30.     Link to Free Full Text:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060891/pdf/ciq073.pdf

 

18. Vidlar A, Vostalova J, Ulrichova J, Student V, Stejskal D, Reichenbach R, Vrbkova J, Ruzicka F, Simanek V. The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms. Br J Nutr. 2010 Oct;104(8):1181-9. Epub 2010 Aug 31.

Link to Free Full Text: http://journals.cambridge.org/download.php?file=%2FBJN%2FBJN104_08%2FS0007114510002059a.pdf&code=b7ca2441dde5e518a239898b8d35813a

 

19. Côté J, Caillet S, Doyon G, Sylvain JF, Lacroix M. Bioactive compounds in cranberries and their biological properties. Crit Rev Food Sci Nutr. 2010 Aug;50(7):666-79.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20694928

20. Jepson RG, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD001321.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18253990

 

21. Jerry Avorn, Mark Monane, Jerry H. Gurwitz, Robert J. Glynn, Igor Choodnovskiy, Lewis A. Lipsitz.  Reduction of Bacteriuria and Pyuria After Ingestion of Cranberry Juice . JAMA. 1994;271(10):751-754.

Link to Abstract:  http://jama.ama-assn.org/content/271/10/751.abstract?sid=cc85bce5-985f-42e3-8866-9139c2315eb2

 

22. Amy B. Howell, Ph and Betsy Foxman, PhD. Cranberry Juice and Adhesion of Antibiotic-Resistant Uropathogens.  JAMA 2002; 271(10):751-754.

Link to Full Text: http://jama.ama-assn.org/content/287/23/3082.long

 

23. Stothers L. A randomized trial to evaluate effectiveness and ost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. The Canadian Journal or Urology 2002; 9:1558-1562.

Link to Abastract: http://www.ncbi.nlm.nih.gov/pubmed?term=cranberry%20stothers

 

24. Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature.Consult Pharm.  2012 Jan;27(1):58-65.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22231999

 

25. Liu H, Liu H, Wang W, Khoo C, Taylor J, Gu L.Cranberry phytochemicals inhibit glycation of human hemoglobin and serum albumin by scavenging reactive carbonyls.

Food Funct. 2011 Aug;2(8):475-82. Epub 2011 Aug 8.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21826359

 

26. Basu A, Betts NM, Ortiz J, Simmons B, Wu M, Lyons TJ. Low-energy cranberry juice decreases lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome. Nutr Res. 2011 Mar;31(3):190-6.

Link to Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075541/pdf/nihms276181.pdf

 

27. Wilson T, Singh AP, Vorsa N, Goettl CD, Kittleson KM, Roe CM, Kastello GM, Ragsdale FR. Human glycemic response and phenolic content of unsweetened cranberry juice.  J Med Food. 2008 Mar;11(1):46-54.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18361737

 

28. Wilson T, Meyers SL, Singh AP, Limburg PJ, Vorsa N. Favorable glycemic response of type 2 diabetics to low-calorie cranberry juice. J Food Sci. 2008 Nov;73(9):H241-5.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19021808

 

29. Ruel G, Pomerleau S, Couture P, Lemieux S, Lamarche B, Couillard C. Plasma matrix metalloproteinase (MMP)-9 levels are reduced following low-calorie cranberry juice supplementation in men. J Am Coll Nutr. 2009 Dec;28(6):694-701.

Link to Full Text: http://www.jacn.org/content/28/6/694.full.pdf+html

 

 

Chanca Piedra Research

 

Chanca Piedra (Phyllanthus niruri) is a plant from the amazon rain forest whose name is translated from Spanish as "Stone Break". Chanca Piedra has a long traditional history of use for urinary health but also has been the subject of substantial scientific research. As with cranberry, we use it for its urinary health, but traditional and scientifically documented benefits include many other functions.

 

1. Boim MA, Heilberg IP, Schor N. Int Braz J Urol. Phyllanthus niruri as a promising alternative treatment for nephrolithiasis. 2010 Nov-Dec;36(6):657-64; discussion 664.

Link to Full Text: http://www.brazjurol.com.br/november_december_2010/Boim_657_664.htm

 

2. Narayanan AS, Raja SS, Ponmurugan K, Kandekar SC, Natarajaseenivasan K, Maripandi A, Mandeel QA. Antibacterial activity of selected medicinal plants against multiple antibiotic resistant uropathogens: a study from Kolli Hills, Tamil Nadu, India. Benef Microbes. 2011 Sep;2(3):235-43. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21986363

3. Murugaiyah V, Chan KL.Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. J Ethnopharmacol. 2009 Jul 15;124(2):233-9. Epub 2009 May 3.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19397979

 

4. Manjrekar AP, Jisha V, Bag PP, Adhikary B, Pai MM, Hegde A, Nandini M. Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl4 induced hepatotoxic rats. Indian J Exp Biol. 2008 Jul;46(7):514-20.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18807755

 

5.  Barros ME, Lima R, Mercuri LP, Matos JR, Schor N, Boim MA.Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis. Urol Res. 2006 Dec;34(6):351-7. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16896689

6. Freitas AM, Schor N, Boim MA. The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation. BJU Int. 2002 Jun;89(9):829-34. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/12010223

7. Nishiura JL, Campos AH, Boim MA, Heilberg IP, Schor N. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol Res. 2004 Oct;32(5):362-6. Epub 2004 Jun 19.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15221244

 

8. Campos AH, Schor N. Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells: its role in urolithiasis.Nephron. 1999;81(4):393-7.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10095174

9. Calixto JB, Santos AR, Cechinel Filho V, Yunes RA. A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential. Med Res Rev. 1998 Jul;18(4):225-58. Review. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/9664291

10. Ranilla LG, Apostolidis E, Shetty K.Antimicrobial Activity of an Amazon Medicinal Plant (Chancapiedra) (Phyllanthus niruri L.) against Helicobacter pylori and Lactic Acid Bacteria.Phytother Res. 2011 Oct 28. doi: 10.1002/ptr.3646. [Epub ahead of print]

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22034238

 

11. Ranilla LG, Kwon YI, Apostolidis E, Shetty K. Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America. Bioresour Technol. 2010 Jun;101(12):4676-89. Epub 2010 Feb 25.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20185303

 

12. Asare GA, Addo P, Bugyei K, Gyan B, Adjei S, Otu-Nyarko LS, Wiredu EK, Nyarko A. Acute toxicity studies of aqueous leaf extract of Phyllanthus niruri. Interdiscip Toxicol. 2011 Dec;4(4):206-10.

Link to Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274729/pdf/ITX-4-206.pdf

 

14. Asare GA, Bugyei K, Sittie A, Yahaya ES, Gyan B, Adjei S, Addo P, Wiredu EK, Adjei DN, Nyarko AK.Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae). Genet Mol Res. 2012 Jan 13;11(1):100-11.

Link to Full Text: http://www.geneticsmr.com//year2012/vol11-1/pdf/gmr1315.pdf

 

15. Amin ZA, Abdulla MA, Ali HM, Alshawsh MA, Qadir SW. Assessment of In vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of Phyllanthus niruri. J Sci Food Agric. 2012 Jan 9. doi: 10.1002/jsfa.5554. [Epub ahead of print]

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22231455

 

16. Boeira VT, Leite CE, Santos AA Jr, Edelweiss MI, Calixto JB, Campos MM, Morrone FB. Effects of the hydroalcoholic extract of Phyllanthus niruri and its isolated compounds on cyclophosphamide-induced hemorrhagic cystitis in mouse. Naunyn Schmiedebergs Arch Pharmacol. 2011 Sep;384(3):265-75. doi: 10.1007/s00210-011-0668-0. Epub 2011 Jul 23.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21789632

17. Okoli CO, Obidike IC, Ezike AC, Akah PA, Salawu OA. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharm Biol. 2011 Mar;49(3):248-55. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21323477

18. Obidike IC, Salawu OA, Ndukuba M, Okoli CO, Osunkwo UA. The Anti-Inflammatory and Antinociceptive Properties of the Chloroform Fraction From Phyllanthus niruri Plant Is Mediated via the Peripheral Nervous System. J Diet Suppl. 2010 Dec;7(4):341-50. Epub 2010 Oct 11.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22432563

 

19. Woottisin S, Hossain RZ, Yachantha C, Sriboonlue P, Ogawa Y, Saito S. Effects of Orthosiphon grandiflorus, Hibiscus sabdariffa and Phyllanthus amarus extracts on risk factors for urinary calcium oxalate stones in rats. J Urol. 2011 Jan;185(1):323-8.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21075390

20. Nworu CS, Akah PA, Okoye FB, Esimone CO. Aqueous extract of Phyllanthus niruri (Euphorbiaceae) enhances the phenotypic and functional maturation of bone marrow-derived dendritic cells and their antigen-presentation function. Immunopharmacol Immunotoxicol. 2010 Sep;32(3):393-401. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20095802

21. Huang ST, Wang CY, Yang RC, Wu HT, Yang SH, Cheng YC, Pang JH.Ellagic Acid, the Active Compound of Phyllanthus urinaria, Exerts In Vivo Anti-angiogenic Effect and Inhibits MMP-2 Activity. Evid Based Complement Alternat Med. . [Epub ahead of print]

Link to Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095481/pdf/ECAM2011-215035.pdf

 

22. Sharma P, Parmar J, Verma P, Sharma P, Goyal PK. Anti-tumor activity of Phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asian Pac J Cancer Prev. 2009;10(6):1089-94.     Link to Full Text: http://www.apocpcontrol.org/page/popup_paper_file_view.php?pno=MTA4OV9jX1NoYSZrY29kZT0xMTEz&pgubun=i

 

23.  Thippeswamy AH, Shirodkar A, Koti BC, Sadiq AJ, Praveen DM, Swamy AH, Patil M. Protective role of Phyllantus niruri extract in doxorubicin-induced myocardial toxicity in rats.

Indian J Pharmacol. 2011 Feb;43(1):31-5.

 

24. Sarkar MK, Sil PC. Prevention of tertiary butyl hydroperoxide induced oxidative impairment and cell death by a novel antioxidant protein molecule isolated from the herb, Phyllanthus niruri. Toxicol In Vitro. 2010 Sep;24(6):1711-9. Epub 2010 May 25.

25. Sarkar MK, Sil PC. Hepatocytes are protected by herb Phyllanthus niruri protein isolate against thioacetamide toxicity. Pathophysiology. 2007 Oct;14(2):113-20.

26. Shakil NA, Pankaj, Kumar J, Pandey RK, Saxena DB. Nematicidal prenylated flavanones from Phyllanthus niruri. Phytochemistry. 2008 Feb;69(3):759-64. Epub 2007 Sep 29.

27. Bagalkotkar G, Sagineedu SR, Saad MS, Stanslas J. Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review.  J Pharm Pharmacol. 2006 Dec;58(12):1559-70. Review.

28. Iizuka T, Nagai M, Taniguchi A, Moriyama H, Hoshi K. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol Pharm Bull. 2007 Feb;30(2):382-4.

 

28. Bhattacharjee R, Sil PC. Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem Toxicol. 2007 May;45(5):817-26. Epub 2006 Nov 11.

29.  Chatterjee M, Sil PC. Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian J Biochem Biophys. 2006 Oct;43(5):299-305.

30. Murugaiyah V, Chan KL. Antihyperuricemic lignans from the leaves of Phyllanthus niruri. Planta Med. 2006 Nov;72(14):1262-7. Epub 2006 Sep

31. Iizuka T, Moriyama H, Nagai M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol Pharm Bull. 2006 Jan;29(1):177-9.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16394535

 

32. Mellinger CG, Carbonero ER, Noleto GR, Cipriani TR, Oliveira MB, Gorin PA, Iacomini M. Chemical and biological properties of an arabinogalactan from Phyllanthusniruri. J Nat Prod. 2005 Oct;68(10):1479-83. Link to Absract: http://www.ncbi.nlm.nih.gov/pubmed/16252911

 

 

Dandelion Root Research

1. Chatterjee SJ, Ovadje P, Mousa M, Hamm C, Pandey S. The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evid Based Complement Alternat Med. 2011;2011:129045. Epub 2010 Dec 30.

Link to Free Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018636/?tool=pubmed

 

2. Ovadje P, Chatterjee S, Griffin C, Tran C, Hamm C, Pandey S. Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract.  J Ethnopharmacol. 2011 Jan 7;133(1):86-91. Epub 2010 Sep 16.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018636/?tool=pubmed

 

3. Domitrović R, Jakovac H, Romić Z, Rahelić D, Tadić Z. Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice. J Ethnopharmacol. 2010 Aug 9;130(3):569-77. Epub 2010 Jun 2.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20561925

 

4.. Mahesh A, Jeyachandran R, Cindrella L, Thangadurai D, Veerapur VP, Muralidhara Rao D.Hepatocurative potential of sesquiterpene lactones of Taraxacum officinale on carbon tetrachloride induced liver toxicity in mice. Acta Biol Hung. 2010 Jun;61(2):175-90. 

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20519172

 

5. You Y, Yoo S, Yoon HG, Park J, Lee YH, Kim S, Oh KT, Lee J, Cho HY, Jun W. In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacum officinale (dandelion) root against alcohol-induced oxidative stress. Food Chem Toxicol. 2010 Jun;48(6):1632-7. Epub 2010 Mar 27. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20347918

6. Choi UK, Lee OH, Yim JH, Cho CW, Rhee YK, Lim SI, Kim YCInt. Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits.

 J Mol Sci. 2010 Jan 6;11(1):67-78.

Link to Free Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820990/?tool=pubmed

 

7. Ung-Kyu Choi,1 Ok-Hwan Lee,2,* Joo Hyuk Yim,3 Chang-Won Cho,3 Young Kyung Rhee,3 Seong-Il Lim,3 and Young-Chan Kim3,* Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits. Int J Mol Sci. 2010 January; 11(1): 67–78.

Link to Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820990/?tool=pubmed

 

8. Schütz K, Carle R, Schieber A. Taraxacum--a review on its phytochemical and pharmacological profile. J Ethnopharmacol. 2006 Oct 11;107(3):313-23. Epub 2006 Jul 22.

Link to abstract: http://www.ncbi.nlm.nih.gov/pubmed/16950583

 

9. Schütz K, Kammerer DR, Carle R, Schieber A. Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2005;19(2):179-86.Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15593267

10. Trojanová I, Rada V, Kokoska L, Vlková E. The bifidogenic effect of Taraxacum officinale root. Fitoterapia. 2004 Dec;75(7-8):760-3.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15567259

 

11. Hussain Z, Waheed A, Qureshi RA, Burdi DK, Verspohl EJ, Khan N, Hasan M. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phytother Res. 2004 Jan;18(1):73-7.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/14750205

 

12. Kashiwada Y, Takanaka K, Tsukada H, Miwa Y, Taga T, Tanaka S, Ikeshiro Y. Sesquiterpene glucosides from anti-leukotriene B4 release fraction of Taraxacum officinale.

J Asian Nat Prod Res. 2001;3(3):191-7.Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11491394

 

13. Hata K, Ishikawa K, Hori K, Konishi T. Differentiation-inducing activity of lupeol, a lupane-type triterpene from Chinese dandelion root (Hokouei-kon), on a mouse melanoma cell line. Biol Pharm Bull. 2000 Aug;23(8):962-7. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10963304

14. Kisiel W, Barszcz B.Further sesquiterpenoids and phenolics from Taraxacum officinale. Fitoterapia. 2000 Jun;71(3):269-73. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10844166

15. Bogacheva AM, Rudenskaya GN, Preusser A, Tchikileva IO, Dunaevsky YE, Golovkin BN, Stepanov VM. A new subtilisin-like proteinase from roots of the dandelion Taraxacum officinale Webb S. L. Biochemistry (Mosc). 1999 Sep;64(9):1030-7.

Link to Free  Full Text: http://protein.bio.msu.ru/biokhimiya/contents/v64/full/64091224.html

 

16. Takasaki M, Konoshima T, Tokuda H, Masuda K, Arai Y, Shiojima K, Ageta H. Anti-carcinogenic activity of Taraxacum plant. I. Biol Pharm Bull. 1999 Jun;22(6):602-5.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10408234

 

17. Takasaki M, Konoshima T, Tokuda H, Masuda K, Arai Y, Shiojima K, Ageta H. Anti-carcinogenic activity of Taraxacum plant. II. Biol Pharm Bull. 1999 Jun;22(6):606-10. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10408235

18. Taraxalisin -- a serine proteinase from dandelion Taraxacum officinale Webb s.l. Rudenskaya GN, Bogacheva AM, Preusser A, Kuznetsova AV, Dunaevsky YaE, Golovkin BN, Stepanov VM. FEBS Lett. 1998 Oct 23;437(3):237-40.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/9824298

19. Williams CA, Goldstone F, Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry. 1996 May;42(1):121-7. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/8728061

 

 

 

Uva Ursi (Arctostaphylos uva-ursi) Research

 

1. Lee HJ, Kim KW. Anti-inflammatory effects of arbutin in lipopolysaccharide-stimulated BV2 microglial cells. Inflamm Res. 2012 Apr 10. [Epub ahead of print]

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22487852

 

2. Li H, Jeong YM, Kim SY, Kim MK, Kim DS. Arbutin inhibits TCCSUP human bladder cancer cell proliferation via up-regulation of p21.Pharmazie. 2011 Apr;66(4):306-9.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21612160

 

3. Alam P, Alqasoumi SI, Shakeel F, Abdel-Kader MS. HPTLC densitometric analysis of arbutin in bulk drug and methanolic extracts of Arctostaphylos uva-ursi. Nat Prod Res. 2011 Oct;25(17):1671-5. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21331974

4. Takada K, Nakane T, Masuda K, Ishii H. Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells. Phytomedicine. 2010 Dec 1;17(14):1114-9. Epub 2010 Jun 25.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20579861

 

5. Head KA. Natural approaches to prevention and treatment of infections of the lower urinary tract. Altern Med Rev. 2008 Sep;13(3):227-44.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18950249

6. Chauhan B, Yu C, Krantis A, Scott I, Arnason JT, Marles RJ, Foster BC. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007 Nov;85(11):1099-107. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18066112

7. Yarnell E. Botanical medicines for the urinary tract.  World J Urol. 2002 Nov;20(5):285-93. Epub 2002 Oct 17.Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/12522584

8. Schindler G, Patzak U, Brinkhaus B, von Niecieck A, Wittig J, Krähmer N, Glöckl I, Veit M.Urinary excretion and metabolism of arbutin after oral administration of Arctostaphylos uvae ursi extract as film-coated tablets and aqueous solution in healthy humans. J Clin Pharmacol. 2002 Aug;42(8):920-7. Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/12162475

9. Newton M, Combest W, Kosier JH. Select herbal remedies used to treat common urologic conditions.Urol Nurs. 2001 Jun;21(3):232-4.

10. Grases F, Melero G, Costa-Bauzá A, Prieto R, March JG. Urolithiasis and phytotherapy. Int Urol Nephrol. 1994;26(5):507-11.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/7860196

 

11. Matsuda H, Nakamura S, Tanaka T, Kubo M.[Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment]. Yakugaku Zasshi. 1992 Sep;112(9):673-7. Japanese.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1469616

 

12. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR.Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice. Acta Diabetol Lat. 1989 Jan-Mar;26(1):51-5.

Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/2750445

 

13. Frohne D.[The urinary disinfectant effect of extract from leaves uva ursi].Planta Med. 1970 Jan;18(1):1-25. German. No abstract available.

 

   

 



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